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  1. Hepatic failure has been associated with reported therapeutic use of acetaminophen by alcoholic patients. The highest risk period for alcoholic patients is immediately after discontinuation of alcohol intake. ...

    Authors: EK Kuffner, JL Green, GM Bogdan, PC Knox, RB Palmer, K Heard, JT Slattery and RC Dart
    Citation: BMC Medicine 2007 5:13
    Content type: Research article Published on:

  2. The CONSORT statement specifies the need for a balanced presentation of both benefits and harms of medical interventions in trial reports. However, invitations to screening and newspaper articles often emphasi...

    Authors: Karsten Juhl Jørgensen, Anders Klahn and Peter C Gøtzsche
    Citation: BMC Medicine 2007 5:12
    Content type: Research article Published on:

  3. Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preve...

    Authors: Heinz-J Schmitt, Robert Booy, Robert Aston, Pierre Van Damme, R Fabian Schumacher, Magda Campins, Carlos Rodrigo, Terho Heikkinen, Catherine Weil-Olivier, Adam Finn, Per Olcén, David Fedson and Heikki Peltola
    Citation: BMC Medicine 2007 5:11
    Content type: Debate Published on:

  4. In maternal medicine, research evidence is scattered making it difficult to access information for clinical decision making. Systematic reviews of good methodological quality are essential to provide valid inf...

    Authors: Lumaan Sheikh, Shelley Johnston, Shakila Thangaratinam, Mark D Kilby and Khalid S Khan
    Citation: BMC Medicine 2007 5:10
    Content type: Research article Published on:

  5. Onchocerciasis is a leading cause of blindness worldwide, hence elimination of the infection is an important health priority. Community-based treatment programs with ivermectin form the basis of control progra...

    Authors: Juan Carlos Vieira, Philip J Cooper, Raquel Lovato, Tamara Mancero, Jorge Rivera, Roberto Proaño, Andrea A López, Ronald H Guderian and José Rumbea Guzmán
    Citation: BMC Medicine 2007 5:9
    Content type: Research article Published on:

  6. Male students and students from ethnic minorities have been reported to underperform in undergraduate medical examinations. We examined the effects of ethnicity and gender on pass rates in UK medical graduates...

    Authors: Neil G Dewhurst, Chris McManus, Jennifer Mollon, Jane E Dacre and Allister J Vale
    Citation: BMC Medicine 2007 5:8
    Content type: Research article Published on:

  8. To our knowledge, no study to date has investigated the prescribing patterns of immunomodulatory agents (IMAs) in an outpatient setting in the United States. To address this issue, we performed retrospective d...

    Authors: Jagannadha R Avasarala, Cormac A O'Donovan, Steve E Roach, Fabian Camacho and Steven R Feldman
    Citation: BMC Medicine 2007 5:6
    Content type: Research article Published on:

  9. Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel activated by cyclic AMP (cAMP). The mos...

    Authors: Isabelle Sermet-Gaudelus, Michel Renouil, Anne Fajac, Laure Bidou, Bastien Parbaille, Sébastien Pierrot, Nolwen Davy, Elise Bismuth, Philippe Reinert, Gérard Lenoir, Jean François Lesure, Jean Pierre Rousset and Aleksander Edelman
    Citation: BMC Medicine 2007 5:5
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2018 16:159

  10. The need to publish corrections to scientific articles, and occasionally to retract them, has been recognized for decades. However very little emphasis has been attached to how this is done, provided that the ...

    Authors: Melissa L Norton and Deborah C Saltman
    Citation: BMC Medicine 2007 5:4
    Content type: Commentary Published on:

  12. Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a ...

    Authors: Per Kjaer, Tom Bendix, Joan Solgaard Sorensen, Lars Korsholm and Charlotte Leboeuf-Yde
    Citation: BMC Medicine 2007 5:2
    Content type: Research article Published on:

  13. The increased sympathetic nervous activity in patients with obstructive sleep apnea (OSA) is largely responsible for the high prevalence of arterial hypertension, and it is suggested to adversely affect trigly...

    Authors: Nina K Bartels, Jan Börgel, Stefan Wieczorek, Nikolaus Büchner, Christoph Hanefeld, Daniel Bulut, Andreas Mügge, Lars C Rump, Bernd M Sanner and Jörg T Epplen
    Citation: BMC Medicine 2007 5:1
    Content type: Research article Published on:

  14. Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion. Moreover, collagen-dense breast tissue increases t...

    Authors: Paolo P Provenzano, Kevin W Eliceiri, Jay M Campbell, David R Inman, John G White and Patricia J Keely
    Citation: BMC Medicine 2006 4:38
    Content type: Research article Published on:

  15. Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pe...

    Authors: Sairam V Jabba, Alisha Oelke, Ruchira Singh, Rajanikanth J Maganti, Sherry Fleming, Susan M Wall, Lorraine A Everett, Eric D Green and Philine Wangemann
    Citation: BMC Medicine 2006 4:37
    Content type: Research article Published on:

  16. Neural tube defects (NTDs) are among the most common of all human congenital defects. Over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significa...

    Authors: James O Ebot Enaw, Huiping Zhu, Wei Yang, Wei Lu, Gary M Shaw, Edward J Lammer and Richard H Finnell
    Citation: BMC Medicine 2006 4:36
    Content type: Research article Published on:

  17. Population impact measures (PIMs) have been developed as tools to help policy-makers with locally relevant decisions over health risks and benefits. This involves estimating and prioritising potential benefits...

    Authors: Richard F Heller, Islay Gemmell, Richard Edwards, Iain Buchan, Shally Awasthi and James A Volmink
    Citation: BMC Medicine 2006 4:35
    Content type: Research article Published on:

  18. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene has been found to be associated with type 2 diabetes in case-control studies. We aimed to estimate associations of the marker rs7903146 (C/T) poly...

    Authors: David Melzer, Anna Murray, Alison J Hurst, Michael N Weedon, Stefania Bandinelli, Anna Maria Corsi, Luigi Ferrucci, Guiseppe Paolisso, Jack M Guralnik and Timothy M Frayling
    Citation: BMC Medicine 2006 4:34
    Content type: Research article Published on:

  19. Australian epidemiologists have recognised that lay readers have difficulty understanding statistical graphs in reports on population health. This study aimed to provide evidence for graph design improvements ...

    Authors: David J Muscatello, Andrew Searles, Robin Macdonald and Louisa Jorm
    Citation: BMC Medicine 2006 4:33
    Content type: Research article Published on:

  21. The human immunodeficiency virus (HIV) burden among adults in India is estimated officially by direct extrapolation of annual sentinel surveillance data from public-sector antenatal and sexually transmitted in...

    Authors: Lalit Dandona, Vemu Lakshmi, Talasila Sudha, G Anil Kumar and Rakhi Dandona
    Citation: BMC Medicine 2006 4:31
    Content type: Research article Published on:

  23. We hypothesised that subjects at familial high risk of developing schizophrenia would have a reduction over time in grey matter, particularly in the temporal lobes, and that this reduction may predict schizoph...

    Authors: Dominic E Job, Heather C Whalley, Andrew M McIntosh, David GC Owens, Eve C Johnstone and Stephen M Lawrie
    Citation: BMC Medicine 2006 4:29
    Content type: Research article Published on:

  24. Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation fo...

    Authors: Frank Pajonk, Anja Riedisser, Michael Henke, William H McBride and Bernd Fiebich
    Citation: BMC Medicine 2006 4:28
    Content type: Research article Published on:

  25. Accurate reporting of adverse events occurring after vaccination is an important component of determining risk-benefit ratios for vaccinations. Controversy has developed over alleged underreporting of adverse ...

    Authors: Walter R Schumm
    Citation: BMC Medicine 2006 4:27
    Content type: Correspondence Published on:

  26. With an influenza pandemic seemingly imminent, we constructed a model simulating the spread of influenza within the community, in order to test the impact of various interventions.

    Authors: Fabrice Carrat, Julie Luong, Hervé Lao, Anne-Violaine Sallé, Christian Lajaunie and Hans Wackernagel
    Citation: BMC Medicine 2006 4:26
    Content type: Research article Published on:

  28. Many risk factors for fractures have been documented, including low bone-mineral density (BMD) and a history of fractures. However, little is known about the short-term absolute risk (AR) of fractures and the ...

    Authors: Antonia CM van Geel, Piet P Geusens, Ivo F Nagtzaam, Cyril MJR Schreurs, Danny JM van der Voort, Paula ELM Rinkens, Arnold DM Kester and Geert-Jan Dinant
    Citation: BMC Medicine 2006 4:24
    Content type: Research article Published on:

  29. We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histolog...

    Authors: Guy H Neild, Manuel Rodriguez-Justo, Catherine Wall and John O Connolly
    Citation: BMC Medicine 2006 4:23
    Content type: Research article Published on:

  31. Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however th...

    Authors: Avi Bleich, Marc Gelkopf, Yuval Melamed and Zahava Solomon
    Citation: BMC Medicine 2006 4:21
    Content type: Research article Published on:

  32. During the past few decades, research has reported gender bias in various areas of clinical and academic medicine. To prevent such bias, a gender perspective in medicine has been requested, but difficulties an...

    Authors: Gunilla Risberg, Katarina Hamberg and Eva E Johansson
    Citation: BMC Medicine 2006 4:20
    Content type: Research article Published on:

  33. The aim of this study was to assess the incidence of sickness absence with psychiatric diagnoses from 1994–2000, and the distribution across gender, age groups, diagnostic groups and regions in a general popul...

    Authors: Gunnel Hensing, Lena Andersson and Sören Brage
    Citation: BMC Medicine 2006 4:19
    Content type: Research article Published on:

  35. No efficacy studies of influenza vaccination given to GPs have yet been published. Therefore, our purpose was to assess the effect of an inactivated influenza vaccine given to GPs on the rate of clinical respi...

    Authors: Michiels Barbara, Philips Hilde, Coenen Samuel, Yane Fernande, Steinhauser Toon, Stuyck Sofie, Denekens Joke and Van Royen Paul
    Citation: BMC Medicine 2006 4:17
    Content type: Research article Published on:

  36. Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood.

    Authors: Per Hall, Alexander Ploner, Judith Bjöhle, Fei Huang, Chin-Yo Lin, Edison T Liu, Lance D Miller, Hans Nordgren, Yudi Pawitan, Peter Shaw, Lambert Skoog, Johanna Smeds, Sara Wedrén, John Öhd and Jonas Bergh
    Citation: BMC Medicine 2006 4:16
    Content type: Research article Published on:

  37. While delirium is common among older adults in acute care hospitals, its prevalence in other settings has been less well studied. We examined delirium prevalence and outcomes in a large cohort of older Canadia...

    Authors: Melissa K Andrew, Susan H Freter and Kenneth Rockwood
    Citation: BMC Medicine 2006 4:15
    Content type: Research article Published on:

  38. The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS® 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses.

    Authors: Siegfried Kasper, Ion-George Anghelescu, Armin Szegedi, Angelika Dienel and Meinhard Kieser
    Citation: BMC Medicine 2006 4:14
    Content type: Research article Published on:

  39. BioMed Central (BMC) requires authors to suggest four reviewers when making a submission. Editors searching for reviewers use these suggestions as a source. The review process of the medical journals in the BMC ...

    Authors: Elizabeth Wager, Emma C Parkin and Pritpal S Tamber
    Citation: BMC Medicine 2006 4:13
    Content type: Research article Published on:

  40. The beneficial effect of aspirin after coronary surgery is established; however, a recent study reported the inability of low doses (100 mg) to inhibit postoperative platelet function. We conducted a double-bl...

    Authors: Eric Lim, Jacqueline Cornelissen, Tom Routledge, Ayyaz Ali, Stephen Kirtland, Linda Sharples, Kate Sheridan, Sarah Bellm, Helen Munday and Stephen Large
    Citation: BMC Medicine 2006 4:12
    Content type: Research article Published on:

  41. Procedural pain relief is sub-optimal in infants, especially small and vulnerable ones. Tetracaine gel 4% (Ametop®, Smith-Nephew) provides pain relief in children and larger infants, but its efficacy in smaller i...

    Authors: Brigitte Lemyre, Rebecca Sherlock, Debora Hogan, Isabelle Gaboury, Colline Blanchard and David Moher
    Citation: BMC Medicine 2006 4:11
    Content type: Research article Published on:

  43. Chronic fatigue syndrome, also known as ME (CFS/ME), is a condition characterised primarily by severe, disabling fatigue, of unknown origin, which has a poor prognosis and serious personal and economic consequ...

    Authors: AJ Wearden, L Riste, C Dowrick, C Chew-Graham, RP Bentall, RK Morriss, S Peters, G Dunn, G Richardson, K Lovell and P Powell
    Citation: BMC Medicine 2006 4:9
    Content type: Study protocol Published on:

  44. Japanese encephalitis (JE) is presumed to be endemic throughout Asia, yet only a few cases have been reported in tropical Asian countries such as Indonesia, Malaysia and the Philippines. To estimate the true d...

    Authors: Komang Kari, Wei Liu, Kompiang Gautama, Mammen P Mammen Jr, John D Clemens, Ananda Nisalak, Ketut Subrata, Hyei Kyung Kim and Zhi-Yi Xu
    Citation: BMC Medicine 2006 4:8
    Content type: Research article Published on:

  46. A recent estimate by the World Health Organization (WHO) suggests that 161 million persons worldwide have visual impairment, including 37 million blind (best-corrected visual acuity less than 3/60 in the bette...

    Authors: Lalit Dandona and Rakhi Dandona
    Citation: BMC Medicine 2006 4:6
    Content type: Research article Published on:

  47. Differences in HLA allele frequencies between the diseased and healthy populations may signify efficient immune responses, a notion that has been successfully tested for infectious diseases or for association ...

    Authors: Joachim Fensterle, Uwe Trefzer, Thomas Berger, Mads Hald Andersen, Selma Ugurel and Jürgen C Becker
    Citation: BMC Medicine 2006 4:5
    Content type: Research article Published on:

  48. Alternating ibuprofen and acetaminophen for the treatment of febrile children is a prevalent practice among physicians and parents, despite the lack of evidence on effectiveness or safety. This randomized, dou...

    Authors: Mona M Nabulsi, Hala Tamim, Ziyad Mahfoud, Mohammad Itani, Ramzi Sabra, Fadi Chamseddine and Mohammad Mikati
    Citation: BMC Medicine 2006 4:4
    Content type: Research article Published on:

  50. As part of the NHS plan it was suggested that all patients receive copies of letters sent to their General Practitioner following outpatient consultations. The former Secretary of State for Health extended thi...

    Authors: Nicola J Roberts and Martyn R Partridge
    Citation: BMC Medicine 2006 4:2
    Content type: Research article Published on:
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