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Articles

Page 8 of 102

  1. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended for patients with KMT2A-rearranged (KMT2A-r) leukemia whereas relapse remains high. We aimed to determine whether intensified condi...

    Authors: Zhongli Hu, Zinan Feng, Shiqi Liu, Hai He, Ying Dong, Zhiping Fan, Yiqing Li, Fen Huang, Na Xu, Can Liu, Yunxin Zeng, Ping Zhu, Ren Lin, Hua Jin, Xiong Zhang, Ruijuan Sun…
    Citation: BMC Medicine 2024 22:605
  2. Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of interventions which are informed by theory- and evidence-based behaviour change strategies, and no in...

    Authors: A. Jennings, O. M. Shannon, R. Gillings, V. Lee, R. Elsworthy, R. Bundy, G. Rao, S. Hanson, W. Hardeman, S-M. Paddick, M. Siervo, S. Aldred, J. C. Mathers, M. Hornberger and A. M. Minihane
    Citation: BMC Medicine 2024 22:600
  3. Low-density lipoprotein cholesterol (LDL-C) is a well-recognized risk factor for cardiovascular diseases. However, several clinical studies demonstrated an inverse association between LDL-C and mortality risk ...

    Authors: Guyu Zeng, Ce Zhang, Ying Song, Zheng Zhang, Jingjing Xu, Zhenyu Liu, Xiaofang Tang, Xiaozeng Wang, Yan Chen, Yongzhen Zhang, Pei Zhu, Xiaogang Guo, Lin Jiang, Zhifang Wang, Ru Liu, Qingsheng Wang…
    Citation: BMC Medicine 2024 22:599
  4. Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in childhood and persists throughout life. The major impediment to successful therapy is anti...

    Authors: Aryan Salahi-Niri, Ali Nabavi-Rad, Tanya Marie Monaghan, Theodore Rokkas, Michael Doulberis, Amir Sadeghi, Mohammad Reza Zali, Yoshio Yamaoka, Evelina Tacconelli and Abbas Yadegar
    Citation: BMC Medicine 2024 22:598
  5. Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an older alternative, warfarin using primary care data in the United Kingdom (UK). However, ...

    Authors: Zixuan Wang, Julian Matthewman, John Tazare, Qiuyan Yu, Ka Shing Cheung, Celine S. L. Chui, Esther W. Y. Chan, Krishnan Bhaskaran, Liam Smeeth, Ian C. K. Wong, Ian J. Douglas and Angel Y. S. Wong
    Citation: BMC Medicine 2024 22:597
  6. Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. To advance our understanding of the ...

    Authors: Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang and Jiangping Song
    Citation: BMC Medicine 2024 22:595
  7. Pain is a complex problem that is triaged, diagnosed, treated, and billed based on which body part is painful, almost without exception. While the “body part framework” guides the organization and treatment of...

    Authors: Daniel S. Barron, Karin Saltoun, Hannah Kiesow, Melanie Fu, Jessica Cohen-Tanugi, Paul Geha, Dustin Scheinost, Zacharia Isaac, David Silbersweig and Danilo Bzdok
    Citation: BMC Medicine 2024 22:594
  8. There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee co...

    Authors: Vasco Iten, Elena Herber, Michael Coslovsky, Elisa Hennings, Rebecca E. Paladini, Tobias Reichlin, Nicolas Rodondi, Andreas S. Müller, Annina Stauber, Juerg H. Beer, Roman Brenner, Giulio Conte, Richard Kobza, Marcello Di Valentino, Patricia Chocano Bedoya, Freschteh Moradi…
    Citation: BMC Medicine 2024 22:593
  9. Evidence indicates that neurodivergent (ND) populations may be more at risk of experiencing adverse childhood experiences (ACEs), compared to neurotypical (NT) populations. However, this evidence has typically...

    Authors: Charley Wilson, Nadia Butler, Zara Quigg, David Moore and Mark Bellis
    Citation: BMC Medicine 2024 22:592
  10. Two phenotypes of insomnia disorder (ID) have been identified based on objective total sleep duration (TST): one with short sleep duration (ISSD) and another with normal sleep duration (INSD). Recent proposals...

    Authors: Haobo Zhang, Zhangwei Lv, Hanfei Chen, Zijie Tang and Xu Lei
    Citation: BMC Medicine 2024 22:591
  11. The overall effect of long-term variability in physiological measures on cardiovascular health of older adults and the underlying mechanic pathway remain uncertain.

    Authors: Wei Liu, Lieyang Fan, Da Shi, Linling Yu, Jiahao Song, Ruyi Liang, Xuefeng Lai, Hao Wang, Yongfang Zhang, Shuhui Wan, Yueru Yang and Bin Wang
    Citation: BMC Medicine 2024 22:590
  12. Limited epidemiological evidence exists regarding the role of healthy eating patterns in reducing the risk of Crohn’s disease (CD) and ulcerative colitis (UC). This study aimed to investigate the association b...

    Authors: Bin Xia, Yan Li, Linmin Hu, Peng Xie, Ningning Mi, Liyuan Lv, Zixin Liang, Yuxuan Sun, Ying Li, Xiaodong Jiang, Guinan Liu, Yuanyuan Feng, Yingxin Zhu, Bo Zhan, Qiangsheng He, Pingguang Lei…
    Citation: BMC Medicine 2024 22:589
  13. Immune checkpoint inhibitors (ICIs) have revolutionized the management of cancer patients, but the emergence of ICI-related endocrinopathies (IREs) has introduced new clinical challenges. Despite worldwide rec...

    Authors: Fateen Ata, Adeel Ahmad Khan, Emad Algorani, Amr Faisal Musaed Alsharafi, Reham Abo Shdid, Mohammad Nofal, Ayman R. Ibrahim, Loai Abdullah, Khalil Youssef El Annan, Tareq Emad Hawash Al-Bkoor, Kakil Ibrahim Rasul, Tarik Elhadd and Haval Surchi
    Citation: BMC Medicine 2024 22:588
  14. The Food and Drug Administration (FDA)’s Accelerated Approval (AA) pathway has increasingly used to authorize market approval of new drugs amid controversy. The present study aims to inform the most recent dat...

    Authors: Xiaofang Zhang, Carl C. Peck, Yaning Wang, Thomas D. Szucs, Wan Sun, Xue Bai, Siyu Chen, Fengzhi Wang and Yangfeng Wu
    Citation: BMC Medicine 2024 22:587
  15. High levels of high-density lipoprotein cholesterol (HDL-C) are previously considered protective against cardiovascular diseases (CVD), but recent studies suggest an increased risk of adverse events at very hi...

    Authors: David Tak Wai Lui, Lanlan Li, Xiaodong Liu, Xi Xiong, Eric Ho Man Tang, Chi Ho Lee, Yu Cho Woo, Brian Hung Hin Lang, Carlos King Ho Wong and Kathryn Choon Beng Tan
    Citation: BMC Medicine 2024 22:586
  16. Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death li...

    Authors: Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang…
    Citation: BMC Medicine 2024 22:585

    The Correction to this article has been published in BMC Medicine 2025 23:83

  17. Globally, dementia care is under strain. Rising rates across ageing populations, coupled with overstretched health and care systems, mean that people living with dementia and their carers are missing out on cr...

    Authors: Ruth Abrams, Johanna Spiers, Jill Maben, Wendy Grosvenor, Morro Touray and Heather Gage
    Citation: BMC Medicine 2024 22:584
  18. Pregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal and semi-allogeneic fetal immune systems is disrupted or challenged. Gestational dia...

    Authors: David Westergaard, Agnete Troen Lundgaard, Kilian Vomstein, Line Fich, Kathrine Vauvert Römmelmayer Hviid, Pia Egerup, Ann-Marie Hellerung Christiansen, Josefine Reinhardt Nielsen, Johanna Lindman, Peter Christoffer Holm, Tanja Schlaikjær Hartwig, Finn Stener Jørgensen, Anne Zedeler, Astrid Marie Kolte, Henrik Westh, Henrik Løvendahl Jørgensen…
    Citation: BMC Medicine 2024 22:583
  19. The maintenance of cognitive function is essential for quality of life and health outcomes in later years. Cognitive impairment, however, remains an undervalued long-term complication of type 2 diabetes by pat...

    Authors: Stanley S. Schwartz, Mary E. Herman, May Thet Hmu Tun, Eugenio Barone and D. Allan Butterfield
    Citation: BMC Medicine 2024 22:582
  20. Exposure to illicit substances during pregnancy may have long-term impacts on children’s neurodevelopment. This study explores subsequent risks for intellectual disability, autistic disorders, and attention de...

    Authors: Vincent Chin-Hung Chen, Charles Tzu-Chi Lee, Shu-I. Wu and Michael Gossop
    Citation: BMC Medicine 2024 22:581
  21. Telomere length (TL) has been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, with some studies finding associations with shorter TL and others with longer TL. In...

    Authors: Karoline H. Skåra, Yunsung Lee, Astanand Jugessur, Håkon K. Gjessing, Abraham Aviv, Ben Brumpton, Øyvind Næss, Álvaro Hernáez, Hans Ivar Hanevik, Per Magnus and Maria C. Magnus
    Citation: BMC Medicine 2024 22:580
  22. The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to envi...

    Authors: L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty and C. P. Walsh
    Citation: BMC Medicine 2024 22:579
  23. Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabape...

    Authors: Ian C. Scott, Noor Daud, James Bailey, Helen Twohig, Samantha L. Hider, Christian D. Mallen, Kelvin P. Jordan and Sara Muller
    Citation: BMC Medicine 2024 22:575
  24. Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the met...

    Authors: Tomás Duraj, Miriam Kalamian, Giulio Zuccoli, Joseph C. Maroon, Dominic P. D’Agostino, Adrienne C. Scheck, Angela Poff, Sebastian F. Winter, Jethro Hu, Rainer J. Klement, Alicia Hickson, Derek C. Lee, Isabella Cooper, Barbara Kofler, Kenneth A. Schwartz, Matthew C. L. Phillips…
    Citation: BMC Medicine 2024 22:578
  25. Sleep is essential for the recovery of patients with disorders of consciousness (DoC). However, few approaches targeting sleep were applied. Melatonin has been shown to enhance sleep efficiency with virtually ...

    Authors: Xinrui Wen, Jie Yu, Genying Zhu, Jinhua Wang, Yangyang Sun, Jiajia Zhou, Jiaye Cai, Fanxia Meng, Yi Ling, Yi Sun, Jiajia Zhao, Fangping He, Qisheng Cheng, Chuan Xu, Jian Gao, Jingqi Li…
    Citation: BMC Medicine 2024 22:576
  26. Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of hepatic and extrahepatic cancers, in particular those linked to obesity. In people with chronic liver disease, aspirin may...

    Authors: Matthew Anson, Jun Shang Poon, Alex E. Henney, David Riley, Gema H. Ibarbaru, Cyril Sieberhagen, Daniel J. Cuthbertson, Uazman Alam and Theresa Hydes
    Citation: BMC Medicine 2024 22:574

    The Correction to this article has been published in BMC Medicine 2025 23:193

  27. Although mortality risk associated with HIV is well described, HIV-exposed uninfected (HEU) young children are also at increased risk of hospitalization and death as compared to HIV-unexposed uninfected (HUU) ...

    Authors: Christopher Lwanga, Peace Aber, Kirkby D. Tickell, Moses M. Ngari, John Mukisa, Michael Atuhairwe, Lindsay Brown, Ezekiel Mupere, Isabel Potani, Lubaba Shahrin, Brooks Morgan, Benson O. Singa, Victoria Nankabirwa, Richard K. Mugambe, Zakaria Mukasa, Judd L. Walson…
    Citation: BMC Medicine 2024 22:573
  28. A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by environmental factors.

    Authors: Charlotte Ling, Magdalena Vavakova, Bilal Ahmad Mir, Johanna Säll, Alexander Perfilyev, Melina Martin, Per-Anders Jansson, Cajsa Davegårdh, Olof Asplund, Ola Hansson, Allan Vaag and Emma Nilsson
    Citation: BMC Medicine 2024 22:572
  29. Syntheses of non-randomized studies of interventions (NRSIs) and randomized controlled trials (RCTs) are increasingly used in decision-making. This study aimed to summarize when NRSIs are included in evidence ...

    Authors: Fan Mei, Minghong Yao, Yuning Wang, Jiayidaer Huan, Yu Ma, Guowei Li, Kang Zou, Ling Li and Xin Sun
    Citation: BMC Medicine 2024 22:571
  30. Understanding the prevalence of diseases and where it is detected and recorded in healthcare settings is important for planning effective prevention and care provision. We examined inequalities in the prevalen...

    Authors: Shaolin Wang, Yiu-Shing Lau, Matt Sutton, Michael Anderson, Christodoulos Kypridemos, Anna Head, Ben Barr, Richard Cookson, Chris Bentley and Laura Anselmi
    Citation: BMC Medicine 2024 22:570
  31. Human papillomavirus (HPV) infection is prevalent among people who are sexually active. This study aimed to compare the levels of behavioral intention to receive free clinician-collected and self-collected sam...

    Authors: Zixin Wang, Siyu Chen, Ngai Sze Wong, Annie Wai-Ling Cheung, Zoe Pui-Yee Tam, Sze Long Chung, Denise Pui-Chung Chan, Phoenix K. H. Mo and Eliza Lai-Yi Wong
    Citation: BMC Medicine 2024 22:569
  32. Chronic pain, regardless of its type, is a significant risk factor for suicide. However, not all individuals with chronic pain also experience suicidal thoughts and behaviors. Better characterization of clinic...

    Authors: Emily DiBlasi, Erin A. Kaufman, Sam Webster, Emily E. Hagn, Andrey A. Shabalin, Danli Chen, Seonggyun Han, Rana Jawish, Eric T. Monson, Michael J. Staley, Brooks R. Keeshin, Anna R. Docherty, Amanda V. Bakian, Akiko Okifuji and Hilary Coon
    Citation: BMC Medicine 2024 22:568
  33. In patients with atrial fibrillation (AF), the impact of peripheral artery disease (PAD) on oral anticoagulant (OAC) therapy use and the risk of outcomes remains unclear.

    Authors: Davide Antonio Mei, Giulio Francesco Romiti, Tommaso Bucci, Bernadette Corica, Jacopo Francesco Imberti, Niccolò Bonini, Marco Vitolo, Alena Shantsila, Hung-Fat Tse, Tze-Fan Chao, Giuseppe Boriani, Marco Proietti and Gregory Y. H. Lip
    Citation: BMC Medicine 2024 22:567
  34. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder marked by the progressive loss of motor neurons. Recent insights into ALS pathogenesis underscore the pivotal role of the gut mic...

    Authors: Renyi Feng, Qingyong Zhu, Ao Wang, Hanzhen Wang, Jiuqi Wang, Pei Chen, Rui Zhang, Dongxiao Liang, Junfang Teng, Mingming Ma, Xuebing Ding and Xuejing Wang
    Citation: BMC Medicine 2024 22:566
  35. Adults with intellectual disability experience more pain than adults without and, despite a higher number of medications being prescribed, may be less likely to receive medication for pain. We conducted a syst...

    Authors: Christine Pacitti, Deborah Cairns, Laura Ward and Barbara I. Nicholl
    Citation: BMC Medicine 2024 22:565
  36. The use of surveillance technologies is becoming increasingly common in inpatient mental health settings, commonly justified as efforts to improve safety and cost-effectiveness. However, their use has been que...

    Authors: Jessica L. Griffiths, Katherine R. K. Saunders, Una Foye, Anna Greenburgh, Ciara Regan, Ruth E. Cooper, Rose Powell, Ellen Thomas, Geoff Brennan, Antonio Rojas-García, Brynmor Lloyd-Evans, Sonia Johnson and Alan Simpson
    Citation: BMC Medicine 2024 22:564

    The Correction to this article has been published in BMC Medicine 2025 23:141

  37. The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the pharmacological interac...

    Authors: Azrin N. Abd-Rahman, Daniel Kaschek, Anne Kümmel, Rebecca Webster, Adam J. Potter, Anand Odedra, Stephen D. Woolley, Stacey Llewellyn, Lachlan Webb, Louise Marquart, Stephan Chalon, Myriam El Gaaloul, James S. McCarthy, Jörg J. Möhrle and Bridget E. Barber
    Citation: BMC Medicine 2024 22:563
  38. The causal pathway between different dietary patterns (DPs) and gastric adenocarcinoma (GA) remains largely unexplored. The study aimed to identify DPs and evaluate how selected nutrients mediate the relations...

    Authors: Alex Richard Costa Silva, Gianfranco Alicandro, Valdete Regina Guandalini, Patrícia Paula da Fonseca Grili, Paulo Pimentel Assumpção, Mônica Santiago Barbosa, Rosane Oliveira de Sant’Ana, Felipe José Fernández Coimbra and Maria Paula Curado
    Citation: BMC Medicine 2024 22:562
  39. It is not clear if conventional liver fat cutoff of 5.56% weight which has been used for identifying fatty liver in western populations is also applicable for Asians. In Asian women of reproductive age, we eva...

    Authors: Priti Mishra, Suresh Anand Sadananthan, Jadegoud Yaligar, Kok Hian Tan, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Marielle V. Fortier, Johan G. Eriksson, Jerry Kok Yen Chan, Shiao-Yng Chan, Dennis Wang, S. Sendhil Velan and Navin Michael
    Citation: BMC Medicine 2024 22:561
  40. Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.

    Authors: Baohua Wang, Yunzhi Zhang, Jun Liu, Bin Deng, Qing Li, Hongmei Liu, Yi Sui, Ning Wang, Qin Xiao, Wei Liu, Yan Chen, Yongsheng Li, Haipeng Jia, Qilong Yuan, Cuiping Wang, Wenjun Pan…
    Citation: BMC Medicine 2024 22:560
  41. Illicit drug toxicity (i.e., overdose) is the leading cause of death in British Columbia (BC) for people aged 10–59. Stimulants are increasingly detected among drug toxicity deaths. As stimulant use and detect...

    Authors: Heather Palis, Kevin Hu, Andrew Tu, Frank Scheuermeyer, John A. Staples, Jessica Moe, Beth Haywood, Roshni Desai, Chloé G. Xavier, Jessica C. Xavier, Alexis Crabtree and Amanda Slaunwhite
    Citation: BMC Medicine 2024 22:479
  42. The relationship between ozone (O3) exposure and blood pressure (BP) remains inconclusive. Given the scarcity of Chinese epidemiological data, more research on this association is of paramount importance, particu...

    Authors: Chen Tang, Yiqin Zhang, Jingping Yi, Zhonghua Lu, Xianfa Xuan, Hanxiang Jiang, Dongbei Guo, Hanyu Xiang, Ting Wu, Jianhua Yan, Siyu Zhang, Yuxin Wang and Jie Zhang
    Citation: BMC Medicine 2024 22:559
  43. The potential impact of specific food additives, common in Western diets, on the risk of developing type 2 diabetes is not well understood. This study focuses on carrageenan, a widely used food additive known ...

    Authors: Robert Wagner, Janine Buettner, Martin Heni, Louise Fritsche, Stephanie Kullmann, Moritz Wagmüller, Andreas Peter, Hubert Preissl, Jürgen Machann, Reiner Jumpertz von Schwartzenberg, Andreas L. Birkenfeld, Ulrich-Frank Pape, Gerrit van Hall, Peter Plomgaard, Hans-Ulrich Häring, Andreas Fritsche…
    Citation: BMC Medicine 2024 22:558
  44. Although microvascular dysfunction is a widespread phenomenon in type 2 diabetes (T2D) and is recognized as a main cause of T2D-aggravated ischemic stroke injury, the underlying mechanisms by which T2D-mediate...

    Authors: Zhenguo Yang, Cheng Huang, Wenhui Huang, Chao Yan, Xueyi Wen, Di Hu, Hesong Xie, Kejing He, Chi Kwan Tsang and Keshen Li
    Citation: BMC Medicine 2024 22:557
  45. The spatial layout of large-scale functional brain networks exhibits considerable inter-individual variability, especially in the association cortex. Research has demonstrated a link between early socioeconomi...

    Authors: Shaoling Zhao, Haowen Su, Jing Cong, Xue Wen, Hang Yang, Peiyu Chen, Guowei Wu, Qingchen Fan, Yiyao Ma, Xiaoyu Xu, Chuanpeng Hu, Hongming Li, Arielle Keller, Adam Pines, Runsen Chen and Zaixu Cui
    Citation: BMC Medicine 2024 22:556
  46. Failure of systemic corticosteroid therapy is common in patients with newly diagnosed acute graft-versus-host disease (aGVHD) above grade II. Mesenchymal stem cells (MSCs) have been used as a tolerable and pot...

    Authors: Erlie Jiang, Kun Qian, Lu Wang, Donglin Yang, Yangliu Shao, Liangding Hu, Yuhang Li, Chen Yao, Mingzhe Han, Xiaoqiang Hou and Daihong Liu
    Citation: BMC Medicine 2024 22:555
  47. Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration. Our objective was to assess the ...

    Authors: Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus and Siri E. Håberg
    Citation: BMC Medicine 2024 22:554

    The Correction to this article has been published in BMC Medicine 2025 23:9

  48. Paracetamol is the most consumed medicine globally. Its accessibility contributes to common overdose. Paracetamol overdose is responsible for > 50% of acute liver failure cases, making it the second most commo...

    Authors: Yufeng Zhou, Silothabo Dliso, Jennie Craske, Andrea Gill, Louise Bracken, Kiran Landa, Philip Arnold, Laura Walker, Ionela Grasim, Gabrielle Seddon, Tao Chen, Andrew S. Davison, Tung-Ting Sham, Barry Smith, Daniel B. Hawcutt and Simon Maher
    Citation: BMC Medicine 2024 22:553