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  1. Digital advance care planning (DACP) is increasingly used globally for patients with life-limiting conditions to support real-time documentation and the sharing of preferences for care. There has been low enga...

    Authors: Matthew J. Allsop, Jacqueline Birtwistle, Michael I. Bennett, Andy Bradshaw, Paul Carder, Catherine J. Evans, Robbie Foy, Ciara Heavin, Barbara Hibbert, Pablo Millares Martin, Sam D. Relton, Suzanne H. Richards, Maureen Twiddy and Katherine E. Sleeman
    Citation: BMC Medicine 2025 23:291
    Content type: Research Published on:

  2. Although most people with cancer now survive long-term, evidence on long-term person-centred outcomes in survivors is limited, particularly relative to people without cancer. We quantified changes in physical ...

    Authors: Yuehan Zhang, Joanne Thandrayen, Kay Soga, Marianne Weber, Bogda Koczwara, Rebekah Laidsaar‑Powell, Chloe Yi Shing Lim, Grace Joshy and Emily Banks
    Citation: BMC Medicine 2025 23:290
    Content type: Research Published on:

  3. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder in the reproductive-age women. The international evidence-based guideline for the assessment and management of PCOS 2023 now sug...

    Authors: Xueqi Yan, Ziyi Yang, Hui Zhao, Gengchen Feng, Shumin Li, Yimeng Li, Yu Sun, Jinlong Ma, Han Zhao, Xueying Gao and Shigang Zhao
    Citation: BMC Medicine 2025 23:289
    Content type: Research Published on:

  4. Significant advancements in treatment and care, as well as early detection, have contributed to an increase in cancer survival rates. Recently, the EAT-Lancet Commission on Food, Planet, Health proposed the “p...

    Authors: Nena Karavasiloglou, Alysha S. Thompson, Giulia Pestoni, Flurina Suter, Keren Papier, Aedín Cassidy, Tilman Kühn and Sabine Rohrmann
    Citation: BMC Medicine 2025 23:286
    Content type: Research Published on:

  5. Intestinal ischemia/reperfusion injury (IIRI) is a life-threatening condition caused by multiple organ and system failures induced by dysbiosis and gut leakage. Metformin has demonstrated efficacy in protectin...

    Authors: Fangyan Wang, Xinyu Wang, Chaoyi Wang, Wangxin Yan, Junpeng Xu, Zhengyang Song, Mingli Su, Jingjing Zeng, Qiannian Han, Gaoyi Ruan, Eryao Zhang and Wantie Wang
    Citation: BMC Medicine 2025 23:285
    Content type: Research Published on:

  6. Most studies on integration of neglected tropical disease programmes have focused on mass drug administration or environmental measures rather than Disease Management, Disability and Inclusion (DMDI). The stud...

    Authors: Oumer Ali, Awoke Mihretu, Natalia Hounsome, Vasso Anagnostopoulou, Stephen A. Bremner, Mersha Kinfe, Asrat Mengiste, Maya Semrau, Abebaw Fekadu and Gail Davey
    Citation: BMC Medicine 2025 23:284
    Content type: Research Published on:

  7. While metabolic pathway alterations are linked to colorectal cancer (CRC), the predictive value of pre-diagnostic metabolomic profiling in CRC risk assessment remains to be clarified. This study evaluated the ...

    Authors: Teresa Seum, Rafael Cardoso, Joshua Stevenson-Hoare, Bernd Holleczek, Ben Schöttker, Michael Hoffmeister and Hermann Brenner
    Citation: BMC Medicine 2025 23:283
    Content type: Research Published on:

  8. This study aimed to determine whether handwriting patterns are altered in individuals experiencing depressive episodes. Additionally, we developed a model for the recognition of major depressive disorder (MDD)...

    Authors: Chong Li, Kunxue Zhang, Qunxing Lin, Shan Huang, Wanying Cheng, Yueshiyuan Lei, Xinyu Zhao and Jiubo Zhao
    Citation: BMC Medicine 2025 23:282
    Content type: Research Published on:

  9. Gram-positive Streptococci is a huge group of different species that are classified based on its hemolytic effect besides the C-substance in the cell wall. This study focuses on the investigation of the prevalenc...

    Authors: Safaa A. Abdel-Karim, Fathy M. Serry, Eman M. Elmasry and Wael A. H. Hegazy
    Citation: BMC Medicine 2025 23:281
    Content type: Research Published on:

  10. An increasing number of autistic adults have entered their later life, but little is known about the disease trajectory in mid- and later adulthood. We aimed to examine the patterns of comorbidity progression ...

    Authors: Yiwei Pu, Feng Li, Tailin Zhu, Jiong Li, Wei Zhou, Lingli Zhang, Jingyu Chen, Qianlong Zhang, Tai Ren and Fei Li
    Citation: BMC Medicine 2025 23:280
    Content type: Research Published on:

  11. Motorway food environments are dominated by roadside restaurants and petrol station stores offering predominantly unhealthy quick-service meals and foods for on-the-go consumption. Improving these environments...

    Authors: Lisanne Geboers, Coosje Dijkstra, Frédérique C. Rongen, Sanne K. Djojosoeparto and Maartje P. Poelman
    Citation: BMC Medicine 2025 23:279
    Content type: Research Published on:

  12. Hepatocellular carcinoma (HCC) is one of the most common cancers. Early detection of HCC helps improve the patients’ 5-year survival rate. Our goal was to identify superior methylation biomarkers to develop a ...

    Authors: Wenhao Teng, Hui Li, Hao Yang, Yu Chen, Liying Xi, Fuli Xin, Aiyuan Zhang, Lihui Yu, Lu Zheng, Ming Wang, Jian Bai, Fayong Ke, Yin Wang, Fuming Sun, Hui Zhang, Lin Wu…
    Citation: BMC Medicine 2025 23:278
    Content type: Research Published on:

  13. Physical therapy is commonly recommended for treating meniscus tears and knee osteoarthritis (KOA). However, data from randomized trials that compare the effectiveness of this treatment with that of glucocorti...

    Authors: Mingzhu Lee, Chao Jing and Kainan Lee
    Citation: BMC Medicine 2025 23:277
    Content type: Research Published on:

  14. Frailty is more prevalent in socio-economically disadvantaged groups; however, little is known about how this translates to differences in the number of years people live with and without frailty. We investiga...

    Authors: David R. Sinclair, Asri Maharani, Andrew Kingston, Terence W. O’Neill and Fiona E. Matthews
    Citation: BMC Medicine 2025 23:276
    Content type: Research Published on:

  15. Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) s...

    Authors: Lujun Shen, Fei Cao, Ying Liu, Gulijiayina Nuerhashi, Letao Lin, Hontong Tan, Chunyong Wen, Yujia Wang, Shuanggang Chen, Hongliang Zou, Lin Xie and Weijun Fan
    Citation: BMC Medicine 2025 23:275
    Content type: Research Published on:

  16. The effects of SARS-CoV-2 infection before or during pregnancy on pregnancy outcomes are still largely unknown. We hypothesized that COVID-19 in early pregnancy is a risk factor for adverse pregnancy outcomes,...

    Authors: Micaela N. Sandoval, Michelle R. Klawans, MacKinsey A. Bach, Jennifer Mikhail, Edward A. Graviss, Tru Cao, Jacqueline G. Parchem, Junaid Husain and Eric Boerwinkle
    Citation: BMC Medicine 2025 23:274
    Content type: Research Published on:

  17. Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced r...

    Authors: Zhenyu Lin, Peng Zhang, Ming Cai, Gang Li, Tao Liu, Kailin Cai, Jing Wang, Junli Liu, Hongli Liu, Weikang Zhang, Jinbo Gao, Chuanqing Wu, Linfang Wang, Zheng Wang, Zhiguo Hou, Hongyi Kou…
    Citation: BMC Medicine 2025 23:273
    Content type: Research Published on:

  18. Existing evidence demonstrates the benefits of integrated palliative care for people with cancer, for improved symptom burden, quality of life for patient and caregiver, and appropriate healthcare resource use...

    Authors: Natasha Bradley, Tracey McConnell, Carolyn Blair, Peter O’Halloran, Gillian Prue, Fiona Lynn, Nia Roberts, Geoff Wong, Elspeth Banks and Joanne Reid
    Citation: BMC Medicine 2025 23:272
    Content type: Review Published on:

  19. Abiraterone is a 17α-hydroxylase/C17-20 lyase inhibitor used for the treatment of metastatic castration-resistant prostate cancer (CRPC). This multi-center, randomized, open-label, active-controlled phase II s...

    Authors: Xiaolin Lu, Tao Dai, Xue Chen, Bin Wu, Hui Chen, Jitao Wu, Dexin Yu, Huixin Ge, Jian Li, Houbao Huang, Tiwu Fan, Linzhong Cheng, Xiaoping Zhang, Xuepei Zhang, Xin Yao, Junli Wei…
    Citation: BMC Medicine 2025 23:271
    Content type: Research Published on:

  20. This study aimed to explore the effects of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on weight loss and diabetes remission in adults with obesity and newly diag...

    Authors: Shi Zhang, Yi Wang, Xincheng Wang, Mingxin Leng, Renjiao Liu, Zhouhuiling Li, Jing Li, Jixuan Xiao, Dangmin Hou, Xinying Gao and Chunjun Li
    Citation: BMC Medicine 2025 23:270
    Content type: Research Published on:

  21. Plant-based diets are gaining popularity due to their well-documented cardiometabolic benefits and environmental sustainability. However, these diets are often lower in specific micronutrients such as iodine, ...

    Authors: Catharina J. Candussi, William Bell, Alysha S. Thompson, Sven Knüppel, Martina Gaggl, Martin Světnička, Jan Gojda, Aedín Cassidy, Cornelia Weikert, Reynalda Córdova and Tilman Kühn
    Citation: BMC Medicine 2025 23:269
    Content type: Research Published on:

  22. While excess weight in adulthood and childhood has been associated with increased cancer risk, the link between body size change from childhood to adulthood and cancer risk requires further investigation. We a...

    Authors: Marko Mandic, Fatemeh Safizadeh, Ben Schöttker, Michael Hoffmeister and Hermann Brenner
    Citation: BMC Medicine 2025 23:268
    Content type: Research Published on:

  23. CT images and circulating tumor cells (CTCs) are indispensable for diagnosing the mediastinal lesions by providing radiological and intra-tumoral information. This study aimed to develop and validate a deep mu...

    Authors: Feng Wang, Minwei Bao, Bo Tao, Fugui Yang, Guangxue Wang and Lei Zhu
    Citation: BMC Medicine 2025 23:267
    Content type: Research Published on:

  24. The close interplay between metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes supports the need to identify beneficial combination therapies of antidiabetic medications targe...

    Authors: Minyoung Lee, Sukchul Hong, Yongin Cho, Hyungjin Rhee, Min Heui Yu, Jaehyun Bae, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang and Bong-Soo Cha
    Citation: BMC Medicine 2025 23:266
    Content type: Research Published on:

  25. Cardiovascular health (CVH) is a key determinant of mortality, but the comparative effectiveness of different CVH metrics remains uncertain. Life’s Simple 7 (LS7) evaluates seven domains: smoking, body mass in...

    Authors: Xu Zhu, Iokfai Cheang, Yiyang Fu, Sitong Chen, Gengmin Liang, Huaxin Yuan, Ling Zhu, Haifeng Zhang and Xinli Li
    Citation: BMC Medicine 2025 23:265
    Content type: Research Published on:

  26. To evaluate the efficacy and safety of nimotuzumab combined with docetaxel and cisplatin (TPN) as the first-line therapy in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC).

    Authors: Qihua Zou, Yi Cao, Yulin Lai, Yu Fang, Yuchen Zhang, Panpan Liu, Lixia Lu, Hao Wu, Tianying Huang, Ning Su, Zhihua Li, Xicheng Wang, Xiaopeng Tian, Lirong Li, Yingxian Liu, Qingqing Cai…
    Citation: BMC Medicine 2025 23:264
    Content type: Research Published on:

  27. Neurodevelopmental disorders (NDDs) and epileptic syndromes are complex neurological conditions linked by shared abnormal neurobiological processes. Existing therapies mostly target symptoms, rather than addre...

    Authors: Greta Volpedo, Antonella Riva, Lino Nobili, Federico Zara, Teresa Ravizza and Pasquale Striano
    Citation: BMC Medicine 2025 23:263
    Content type: Review Published on:

  28. People living with dementia (PlwD) have a 1.4 times higher risk of hospitalization than people living without dementia. Hospital admissions lead to negative consequences for PlwD and people living with mild co...

    Authors: Julia Misonow, Karin Wolf-Ostermann, Janissa Altona, Annika Schmidt, Susanne Stiefler, Serhat Guenay, André Kratzer, Antonia Keck, Carolin Donath and Elmar Graessel
    Citation: BMC Medicine 2025 23:262
    Content type: Research Published on:

  29. This study investigates the hypothesis that chronic insomnia disorder (CID) is characterized by sex-specific changes in resting-state functional connectivity (rsFC), with certain molecular mechanisms potential...

    Authors: Liyong Yu, Zhifu Shen, Wei Wei, Zeyang Dou, Yucai Luo, Daijie Hu, Wenting Lin, Guangli Zhao, Xiaojuan Hong and Siyi Yu
    Citation: BMC Medicine 2025 23:261
    Content type: Research Published on:

  30. Controversy existed in the prognosis of reversion from mild cognitive impairment (MCI) to normal cognition (NC). We aim to depict the prognostic characteristics of cognition, neuroimaging, and pathology biomar...

    Authors: Hai-Hong Yu, Lan Tan, Meng-Jiao Jiao, Yi-Ju Lv, Xin-Hao Zhang, Chen-Chen Tan and Wei Xu
    Citation: BMC Medicine 2025 23:260
    Content type: Research Published on:

  31. Disparities in neighborhood food environments in the United States, attributed to numerous complex economic, social, and political factors, likely to contribute to disparities in access to healthy food and cog...

    Authors: Boeun Kim, Roland J. Thorpe Jr, Sarah L. Szanton, Paris B. Adkins-Jackson and Laura J. Samuel
    Citation: BMC Medicine 2025 23:259
    Content type: Research Published on:

  32. Genetic generalized epilepsy is characterized by transient episodes of spontaneous abnormal neural activity in anatomically distributed brain regions that ultimately propagate to wider areas. However, the conn...

    Authors: Jie Xia, Siqi Yang, Jiao Li, Yao Meng, Jinpeng Niu, Huafu Chen, Zhiqiang Zhang and Wei Liao
    Citation: BMC Medicine 2025 23:258
    Content type: Research Published on:

  33. Extramedullary myeloma disease (EMD) can present at disease relapse (secondary EMD, sEMD) and confers an aggressive clinical course. Identifying predictive markers for sEMD is crucial for clinical management.

    Authors: Yi Tao, Shi-Wei Jin, Zhe Wang, Mengmeng Pan, Wanyan Ouyang, Jie Xu, Yuanfang Liu, Yan Wang, Weiping Zhang, Jian Li and Jian-Qing Mi
    Citation: BMC Medicine 2025 23:257
    Content type: Research Published on:

  34. The rising prevalence of mild cognitive impairment (MCI) among older adults in nursing homes necessitates effective interventions to slow the progression to dementia. Integrated social-art interventions have s...

    Authors: Chenshan Huang, Yuanjiao Yan, Wilson Wai San Tam, Wenqian Sun, Yu Ye, Nafang Wang, Yanhong Shi, Ziping Zhu, Danting Chen, Lin Chen, Junyu Zhao, Rong Lin and Hong Li
    Citation: BMC Medicine 2025 23:256
    Content type: Research Published on:

  35. Numerous studies have demonstrated that COVID-19 is associated with an increased risk of new-onset fibromyalgia (FM), which not only significantly impacts patients’ quality of life but also places a substantia...

    Authors: Aihui Liu, PeiLun Liao, Hongyang Jiang, Shan Huang, Shinan Li, James Cheng-Chung Wei and Zhenhua Ying
    Citation: BMC Medicine 2025 23:255
    Content type: Research Published on:

  36. Atherosclerosis is a major contributor to cardiovascular diseases worldwide. Despite advancements in understanding its pathology, significant gaps remain in the molecular characterization of atherosclerotic pl...

    Authors: Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun…
    Citation: BMC Medicine 2025 23:254
    Content type: Research Published on:

  37. People with disabilities encounter significant barriers to social participation due to inaccessible environments and negative attitudes. This study evaluated the effectiveness of a comprehensive disability-inc...

    Authors: Shanquan Chen, Lena Morgon Banks, Mark T. Carew, Elijah Kipchumba, Calum Davey, Munshi Sulaiman and Hannah Kuper
    Citation: BMC Medicine 2025 23:253
    Content type: Research Published on:

  38. Epidemiological studies that have simultaneously explored the effects of placental and cord blood inflammatory cytokine levels on neurodevelopment in offspring, as well as the role of maternal vitamin D in the...

    Authors: Menglong Geng, Zhen Yu, Yafei Wang, Juan Tong, Hui Gao, Hong Gan, Jixing Zhou, Baolin Wang, Peng Ding, Shuangqin Yan, Kun Huang, Xiaoyan Wu and Fangbiao Tao
    Citation: BMC Medicine 2025 23:252
    Content type: Research Published on:

  39. The aim of our study was to determine whether the application of machine learning could predict PASC by using diagnoses from primary care and prescribed medication 1 year prior to PASC diagnosis.

    Authors: Seika Lee, Marta A. Kisiel, Pia Lindberg, Åsa M. Wheelock, Anna Olofsson, Julia Eriksson, Judith Bruchfeld, Michael Runold, Lars Wahlström, Andrei Malinovschi, Christer Janson, Caroline Wachtler and Axel C. Carlsson
    Citation: BMC Medicine 2025 23:251
    Content type: Research Published on:

  40. The incidence of early-onset colorectal cancer (EOCRC) (< 50 years) has been steadily rising, with a parallel increase in metastatic and invasive cases. To elucidate the molecular mechanisms underlying this ag...

    Authors: Siyun Zhou, Lili Yu, Jianhui Zhao, Qian Xiao, Jing Sun, Lijuan Wang, Yuan Zhou, Yadong Lu, Malcolm G Dunlop, Evropi Theodoratou, Honghe Zhang, Kefeng Ding and Xue Li
    Citation: BMC Medicine 2025 23:250
    Content type: Research Published on:

  41. Epidermal growth factor receptor (EGFR) exon 19 insertions (19ins) represent a unique subclass of exon 19 alterations that has a relatively low frequency. Here, we aimed to elucidate the molecular characteristics...

    Authors: Yang Li, Yunfeng Ni, Feng Lv, Yan Shi, Yedan Chen, Xiaoying Wu, Jiaohui Pang, Long Huang, Yang Shao, Tao Wang, Jie Min and Yang Song
    Citation: BMC Medicine 2025 23:249
    Content type: Research Published on:

  42. Orthogeriatric co-management (OGCM) has been proposed as care model for geriatric patients with fragility fractures. However, its impact on nursing home (NH) admissions following non-hip fractures is unclear. ...

    Authors: Daniel Schoene, Kilian Rapp, Patrick Roigk, Clemens Becker, Andrea Jaensch, Claudia Konnopka, Hans-Helmut König, Thomas Friess, Gisela Büchele and Dietrich Rothenbacher
    Citation: BMC Medicine 2025 23:248
    Content type: Research Published on:

  43. Differences in responses to the COVID-19 pandemic among Northwestern European countries have generated extensive discussion. We explore how the impact of the first pandemic wave might have differed, had Belgiu...

    Authors: Pieter de Boer, Fuminari Miura, Giske Lagerweij and Jacco Wallinga
    Citation: BMC Medicine 2025 23:247
    Content type: Research Published on:

  44. Prophylactic azithromycin in pregnancy has been shown to lower infections in birthing parents and newborns, particularly skin and soft tissue infections (SSTIs) which are common in Fiji. We aimed to determine ...

    Authors: Maeve Hume-Nixon, Stephanie Clark, Tupou Ratu, Cattram D. Nguyen, Eleanor F. G. Neal, Kathryn Bright, Aneley Getahun Strobel, Emma Watts, John Hart, James Fong, Eric Rafai, Kelera Sakumeni, Andrew Steer, Ilisapeci Tuibeqa and Fiona M. Russell
    Citation: BMC Medicine 2025 23:246
    Content type: Research Published on:

  45. Circulating linoleic acid (LA) levels have been reported to be associated with various metabolic outcomes. However, the role of LA and its interplay with gut microbiota in gestational diabetes mellitus (GDM) r...

    Authors: Jiahui Qiu, Ping Hu, Fan Li, Yichao Huang, Yunhaonan Yang, Fengjiang Sun, Ping Wu, Yuwei Lai, Yi Wang, Xiangwang He, Yidan Dong, Peiqi Zhang, Shanshan Zhang, Nianwei Wu, Tianlei Wang, Shizhuo Yang…
    Citation: BMC Medicine 2025 23:245
    Content type: Research Published on:

  46. Medications that reduce blood pressure and cholesterol are among the most cost-effective healthcare interventions available, but their delivery remains suboptimal. In 2009, the National Health Service (NHS) He...

    Authors: Zahra Raisi-Estabragh, Stefan Neubauer, Thomas E. Nichols and John Robson
    Citation: BMC Medicine 2025 23:243
    Content type: Matters Arising Published on:

    The original article was published in BMC Medicine 2025 23:242

    The Research article to this article has been published in BMC Medicine 2024 22:1

  48. Authors of a matched cohort study claimed the NHS Health Check programme reduced total mortality 23% and liver cirrhosis incidence 44%. Such impressive results require critical scrutiny, especially as the inte...

    Authors: Karsten Juhl Jørgensen, Minna Johansson and Steven Woloshin
    Citation: BMC Medicine 2025 23:242
    Content type: Matters Arising Published on:

    The Matters Arising to this article has been published in BMC Medicine 2025 23:243

  49. The suspension and/or termination of many programmes funded through the United States Agency for International Development (USAID) by the new US administration has severe short- and long-term negative impacts ...

    Authors: Jessie Jane Khaki, Jil Molenaar, Sulata Karki, Emmanuel Olal, Manuela Straneo, Marie Alice Mosuse, Jovanny Tsuala Fouogue, Bernadette Hensen, Adama Baguiya, Angèle Musau Nkola, Kerry L. M. Wong, Oumar Aly Ba, Amani Kikula, Fassou Mathias Grovogui, Aline Semaan, Anteneh Asefa…
    Citation: BMC Medicine 2025 23:241
    Content type: Debate Published on:

  50. Neurocognitive resilience (NCR) refers to the ability of individuals to maintain cognitive function despite the presence of risk factors for psychosis. Investigating NCR is important as it may help predict the...

    Authors: TianHong Zhang, XiaoChen Tang, YanYan Wei, LiHua Xu, HuiRu Cui, HaiChun Liu, ZiXuan Wang, Tao Chen, LingYun Zeng, YingYing Tang, ZhengHui Yi, ChunBo Li and JiJun Wang
    Citation: BMC Medicine 2025 23:240
    Content type: Research Published on:
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