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  1. Acute Type A Aortic Dissection (aTAAD) is a severe and life-threatening condition. While animal studies have suggested that ketorolac could slow the progression of aortic aneurysms and dissections, clinical da...

    Authors: Zhi-Kang Lv, Hai-Tao Zhang, Xiu-Juan Cai, Wen-Xin Su, Er-Jun Zhu, Hoshun Chong, Xi-Yu Zhu, You-Ru Kong, Yu-Xian Tang, Xin Li, Yuan-Xi Luo, Han-Qing Luo, Hao-Dong Pan, Yan-Hua Sun, Kai Li, Min Jin…
    Citation: BMC Medicine 2025 23:188
    Content type: Research Published on:

  2. Negative symptoms in schizophrenia remain a challenge with limited therapeutic strategies. The novel compound RG7203 promotes reward learning via dopamine D1-dependent signaling and therefore holds promise, es...

    Authors: Wolfgang Omlor, Giacomo Cecere, Gao-Yang Huang, Tobias Spiller, Akhil Ratan Misra, Finn Rabe, Nils Kallen, Matthias Kirschner, Werner Surbeck, Achim Burrer, George Garibaldi, Štefan Holiga, Juergen Dukart, Daniel Umbricht and Philipp Homan
    Citation: BMC Medicine 2025 23:187
    Content type: Research Published on:

  3. Perioperative management and lung function recovery are vital for lung cancer patients. We conducted an open-label, single-center, noninferiority, randomized controlled trial in China to evaluate the efficacy ...

    Authors: Jinming Xu, Heng Ni, Hanyu Zhan, Hongfan Yu, Zhongjie Lu, Jieping Zhang, Hongbo Meng, Lin Hang, Lin Mao, Xiaoying Xu, Xiaojian Ma, Qiongyin Wu, Wen Xu, Danyu Xiang, Yufang Zeng, Di Meng…
    Citation: BMC Medicine 2025 23:186
    Content type: Research Published on:

  4. The low recognition of depression in primary healthcare (PHC) remains a major obstacle to rendering adequate care for people with depression globally. This study aimed to evaluate the feasibility and potential...

    Authors: Abebaw Fekadu, Barkot Milkias, Rahel Birhane, Bethlehem Tekola, Mahlet Yared, Tigist Eshetu, Tomas Getahun, Heidi Lempp, Andre Tylee, Merga Belina, Girmay Medhin, Kassahun Habtamu, Atalay Alem, Crick Lund, Inge Petersen, Graham Thornicroft…
    Citation: BMC Medicine 2025 23:185
    Content type: Research Published on:

  5. Matings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wild-type females yield non-viable eggs, thereby suppressing Ae. aegypti abundance in the field. We evaluated the spillove...

    Authors: Jue Tao Lim, Diyar Mailepessov, Chee Seng Chong, Borame Dickens, Yee Ling Lai, Youming Ng, Deng Lu, Caleb Lee, Li Yun Tan, Grace Chain, Soon Hoe Ho, Chia-Chen Chang, Pei Ma, Somya Bansal, Vernon Lee, Shuzhen Sim…
    Citation: BMC Medicine 2025 23:184
    Content type: Research Published on:

  6. Inflammatory bowel disease (IBD) refers to chronic, recurrent inflammatory intestinal disorders, primarily including Crohn’s disease (CD) and Ulcerative colitis (UC). Numerous studies have elucidated the impor...

    Authors: Yushan Wu, Rui Cheng, Hao Lin, Lili Li, Yongbin Jia, Anna Philips, Tao Zuo and Hu Zhang
    Citation: BMC Medicine 2025 23:183
    Content type: Review Published on:

  7. Diagnosing celiac disease (CD) in individuals adhering to a gluten-free diet (GFD) presents significant challenges. Current guidelines recommend a gluten challenge (GC) lasting at least 6–8 weeks, which has se...

    Authors: Sara Gómez-Aguililla, Sergio Farrais, Natalia López-Palacios, Beatriz Arau, Carla Senosiain, María Corzo, Nora Fernandez-Jimenez, Ángela Ruiz-Carnicer, Fernando Fernández-Bañares, Bárbara P. González-García, Eva Tristán, Ana Montero-Calle, María Garranzo-Asensio, Isabel Casado, Mar Pujals, Juana María Hernández…
    Citation: BMC Medicine 2025 23:182
    Content type: Research Published on:

  9. The incidence of shoulder replacement surgery continues to rise internationally. The aim of this study was to compare revision surgery, reoperations and serious adverse events after shoulder replacement surger...

    Authors: Epaminondas Markos Valsamis, Josefine Beck Larsen, Theis M. Thillemann, Stephen E. Gwilym, Gary S. Collins, Inger Mechlenburg and Jonathan L. Rees
    Citation: BMC Medicine 2025 23:180
    Content type: Research Published on:

  10. There is a lack of data regarding outcomes of therapeutic hypothermia in patients with acute myocardial infarction (AMI) complicated by out-of-hospital cardiac arrest (OHCA). This study aimed to evaluate the e...

    Authors: Oh-Hyun Lee, Seok-Jae Heo, Moon-Hyun Kim, Je-Wook Park, SungA Bae, Minkwan Kim, Ji Woong Roh, Yongcheol Kim, Eui Im, In Hyun Jung and Deok-Kyu Cho
    Citation: BMC Medicine 2025 23:179
    Content type: Research Published on:

  11. Targeted next-generation sequencing (tNGS) enables high-performance tuberculosis (TB) diagnosis and drug resistance prediction directly from clinical samples. However, its applicability to paucibacillary TB, i...

    Authors: Yu Chen, Lichao Fan, Zhong Ren, Yanhong Yu, Jiao Sun, Miaoran Wang, Chang Liu, Ying Zhang, Shuihua Lu, Xuhui Liu and Zhen Huang
    Citation: BMC Medicine 2025 23:178
    Content type: Research Published on:

  12. Major depressive disorder (MDD) often presents alongside physical illnesses, such as a high incidence of subclinical hypothyroidism (SHypo) in patients, highlighting the common occurrence of these comorbiditie...

    Authors: Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu and Zhijian Yao
    Citation: BMC Medicine 2025 23:177
    Content type: Research Published on:

  13. There is emerging evidence that metabolites might be associated with risk of lung cancer, but their relationships have not been fully characterized. We aimed to investigate the association between circulating ...

    Authors: Lan Wu, Jun Yang, Yu Chen, Jiahao Lin, Wenkai Huang and Mengmeng Li
    Citation: BMC Medicine 2025 23:176
    Content type: Research Published on:

  14. The Life’s Essential 8 (LE8) proposed by the American Heart Association for assessing cardiovascular health (CVH) has been demonstrated to be associated with cardiovascular disease, but rarely includes heart f...

    Authors: Wei Hu, Chun-Hua Zhao, Jia-Ning Wang, Zhen-Zhen Shen, Ge Tian, Yue-Qing Huang, Bao-Peng Liu and Cun-Xian Jia
    Citation: BMC Medicine 2025 23:175
    Content type: Research Published on:

  15. High language complexity impairs patients’ understanding and medical outcomes. While messengers accelerate communication, the language complexity of chats between patients and providers is poorly studied. This...

    Authors: Simon-Konstantin Thiem, Lucas Küppers, Benjamin Aretz, Arezoo Bozorgmehr, Arian Karimzadeh, Frauke Leupold and Birgitta Weltermann
    Citation: BMC Medicine 2025 23:174
    Content type: Research Published on:

  16. Compared with conventional transradial access (TRA), distal radial access (DRA) is rarely used for percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) and may b...

    Authors: Zixuan Li, Yujie Wang, Jiahui Song, Senhu Wang, Yuntao Wang, Yongxia Wu, Haotian Wang, Zijing Liu, Rui Yan, Guangyao Zhai and Jincheng Guo
    Citation: BMC Medicine 2025 23:173
    Content type: Research Published on:

  17. Longitudinal cohort studies across the lifespan suggest an association between ultra-processed food (UPF) and depression. However, the effect of UPF on depression and mental health in older adults has not been...

    Authors: Belayneh Mengist, Mojtaba Lotfaliany, Julie A. Pasco, Bruno Agustini, Michael Berk, Malcolm Forbes, Melissa M. Lane, Suzanne G. Orchard, Joanne Ryan, Alice J. Owen, Robyn L. Woods, John J. McNeil and Mohammadreza Mohebbi
    Citation: BMC Medicine 2025 23:172
    Content type: Research Published on:

  18. Rapid urbanization is underway in China. However, the impact of urbanization on frailty remains unclear. This study aims to investigate the relationship between urbanization and frailty among middle-aged and o...

    Authors: Xinlan Xie, Jiaqun Que, Linsu Sun, Tao Sun and Feng Yang
    Citation: BMC Medicine 2025 23:171
    Content type: Research Published on:

  19. We aimed to identify influential drivers of the cost-effectiveness of older adult respiratory syncytial virus (RSV) vaccination in Denmark, Finland, the Netherlands and Valencia-Spain.

    Authors: Xiao Li, Lander Willem, Caroline Klint Johannesen, Arantxa Urchueguía-Fornes, Toni Lehtonen, Richard Osei-Yeboah, Heini Salo, Alejandro Orrico-Sánchez, Javier Díez-Domingo, Mark Jit, Joke Bilcke, Harish Nair and Philippe Beutels
    Citation: BMC Medicine 2025 23:170
    Content type: Research Published on:

  20. Eyeglasses, hearing aids, etc., all serve to enhance the sensory stimuli to enable patients to see or hear things that they would not otherwise be able to, but we have no equivalent technology for olfaction, a...

    Authors: Veronica L. Formanek, Barak M. Spector, Gabriela Zappitelli, Zhenxing Wu and Kai Zhao
    Citation: BMC Medicine 2025 23:169
    Content type: Research Published on:

  22. Obesity and obesity-related cancers contribute to rising healthcare costs and declining life expectancy in the US and improving diet quality plays a crucial role in reversing such trends. Existing studies on t...

    Authors: Qinyun Lin, Xiang Chen, Xukun Xiang, Weixuan Lyu, Congcong Miao, Gaofei Zhang and Ran Xu
    Citation: BMC Medicine 2025 23:167
    Content type: Research Published on:

  24. The suitability of the United States National Academy of Medicine guidelines for gestational weight gain in women with gestational diabetes remains uncertain, raising global concerns. This study aimed to evalu...

    Authors: Katrien Benhalima, Caro Minschart, Ina Geerts, Lieveke Ameye, Bart Van Der Schueren, Roland Devlieger, Annick Bogaerts and Chantal Mathieu
    Citation: BMC Medicine 2025 23:165
    Content type: Research Published on:

  25. Hematopoietic stem cell transplantation (HSCT) is a critical treatment for hematologic disorders such as leukemia, lymphoma, and specific immune deficiencies. Despite its efficacy, challenges such as engraftme...

    Authors: Tzong-Shyuan Tai, Yun-Hsiang Chen, Chao-Ling Yao, Jiun-Han Lin, Yu-Shao Yang, Jai-Wen Shi, Li-Wen Fang, Duen-Wei Hsu, Shu-Chen Kuo and Shu-Ching Hsu
    Citation: BMC Medicine 2025 23:164
    Content type: Research Published on:

  26. We aimed to evaluate the potential independent and interactive associations of tobacco and alcohol use with suicide ideation, plan, and attempt among adolescents, and the role of legal purchase age restriction...

    Authors: Manman Chen, Xijie Wang, Din Son Tan, Huan Wang, Jianhui Guo, Jing Li, Zhiyong Zou, Yu Jiang and Wannian Liang
    Citation: BMC Medicine 2025 23:163
    Content type: Research Published on:

  27. Pathological images of hepatocellular carcinoma (HCC) contain abundant tumor information that can be used to stratify patients. However, the links between histology images and the treatment response have not b...

    Authors: Yixin Li, Ji Xiong, Zhiqiu Hu, Qimeng Chang, Ning Ren, Fan Zhong, Qiongzhu Dong and Lei Liu
    Citation: BMC Medicine 2025 23:162
    Content type: Research Published on:

  28. Maternal hypertension and hyperglycemia are closely related but have distinct impacts on fetal growth and are managed independently. How the interdependence of blood pressure (BP) and glucose levels quantitati...

    Authors: Lijuan Lv, Jingbo Yang, Linjie Li, Chuanyi Huang, Huihua Shi, Yiwen Fang, Lushu Zuo, Ting Liu, Hongli Duan, Jiying Wen, Qing Yang, Amanda Henry, Cha Han, Aihua Yin and Xin Zhou
    Citation: BMC Medicine 2025 23:161
    Content type: Research Published on:

  29. Lenvatinib plus pembrolizumab has demonstrated improved survival compared with doxorubicin or paclitaxel monotherapy in patients with advanced or recurrent endometrial cancers (ECs). However, response rates to...

    Authors: Shao-Jing Wang, Lou Sun, Yu-Hsiang Shih, Ting-Fang Lu, Yen-Fu Chen, Shih-Tien Hsu, Chin-Ku Liu, Sheau-Feng Hwang, Jem-Kun Chen, Hsin-Hua Chen and Chien-Hsing Lu
    Citation: BMC Medicine 2025 23:160
    Content type: Research Published on:

  30. Long-COVID has mostly been investigated in clinical settings. We aimed to assess the risk, subtypes, persistence, and determinants of long-COVID in a prospective population-based study of adults with a history...

    Authors: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso Nogués, Carlota Dobaño, Gemma Moncunill, Rafael de Cid and Judith Garcia-Aymerich
    Citation: BMC Medicine 2025 23:140
    Content type: Research Published on:

  31. To understand potential racial differences in disease susceptibility and develop targeted prevention strategies, it is essential to establish biological differences between racial groups in healthy individuals...

    Authors: Ghazaleh Pourali, Liang Li, Myung Sik Jeon, Jingqin Luo, Chongliang Luo and Adetunji T. Toriola
    Citation: BMC Medicine 2025 23:159
    Content type: Research Published on:

  32. Cervical cancer (CC), primarily caused by human papillomavirus (HPV) infection, remains a significant global health concern. We aimed to comprehensively investigate the epidemiological status of HPV in China.

    Authors: Sirui Han, Mengyue Lin, Mengyu Liu, Shiwan Wu, Pi Guo, Jiubiao Guo, Longxu Xie, Song Qiu, Aijuan Xu, Yingmu Cai and Yequn Chen
    Citation: BMC Medicine 2025 23:158
    Content type: Research Published on:

  33. Current evidence on influenza vaccine effectiveness (VE), which is predominately derived from small high-risk older populations and focuses on specific influenza-related complications, might not be generalizab...

    Authors: Zi-Yang Peng, Yun-Ting Hua, Wan-Ting Huang, Jin-Shang Wu and Huang-Tz Ou
    Citation: BMC Medicine 2025 23:157
    Content type: Research Published on:

  34. Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting eff...

    Authors: Chong-Yin Huang, Meng-Ting Zuo, Xue-Jia Qi, Meng-Die Gong, Wen-Bo Xu, Si-Yu Meng, Jiang-Yu Long, Pi-Shun Li, Zhi-Liang Sun, Xiao-Feng Zheng and Zhao-Ying Liu
    Citation: BMC Medicine 2025 23:156
    Content type: Research Published on:

  35. Vaccine hesitancy, the delay in acceptance or reluctance to vaccinate, ranks among the top threats to global health. Identifying modifiable factors contributing to vaccine hesitancy is crucial for developing t...

    Authors: Omid V. Ebrahimi, Ella Marie Sandbakken, Sigrun Marie Moss, Sverre Urnes Johnson, Asle Hoffart, Sarah Bauermeister, Ole André Solbakken, Lars T. Westlye and Esten H. Leonardsen
    Citation: BMC Medicine 2025 23:155
    Content type: Research Published on:

  36. The National Early Warning Score 2 (NEWS2) has been adopted as the standard approach for early detection of deterioration in clinical settings in the UK, and is also used in many non-UK settings. Limitations h...

    Authors: Victoria Riccalton, Lynsey Threlfall, Ananya Ananthakrishnan, Cen Cong, Madison Milne-Ives, Peta Le Roux, Chris Plummer and Edward Meinert
    Citation: BMC Medicine 2025 23:154
    Content type: Research Published on:

  37. Long-term cost-effectiveness analyses of health behaviour interventions to effectively manage type 2 diabetes mellitus (T2DM) in low-income countries are crucial for minimising economic burden and optimising r...

    Authors: Padam Kanta Dahal, Corneel Vandelanotte, Lal Rawal, Rashidul Alam Mahumud, Grish Paudel, Melanie Lloyd, Yeji Baek, Biraj Karmacharya, Tomohiko Sugishita and Zanfina Ademi
    Citation: BMC Medicine 2025 23:153
    Content type: Research Published on:

  38. We aimed to evaluate the efficacy and safety of cadonilimab (anti-PD-1 and CTLA-4 bispecific antibody) plus TPC chemotherapy (NAB-paclitaxel, cisplatin or lobaplatin, and capecitabine) in patients with recurre...

    Authors: Yaofei Jiang, Weixin Bei, Lin Wang, Nian Lu, Cheng Xu, Hu Liang, Liangru Ke, Yanfang Ye, Shuiqing He, Shuhui Dong, Qin Liu, Chuanrun Zhang, Xuguang Wang, Weixiong Xia, Chong Zhao, Ying Huang…
    Citation: BMC Medicine 2025 23:152
    Content type: Research Published on:

  39. During adolescence, accurate diagnostic criteria and/or identification of adolescents “at risk” of polycystic ovary syndrome (PCOS) are critical to establish appropriate screening, treatment, and lifelong heal...

    Authors: Alexia S Peña, Selma Feldman Witchel, Jacky Boivin, Tania S. Burgert, Carolyn Ee, Kathleen M Hoeger, Marla E. Lujan, Aya Mousa, Sharon Oberfield, Chau Thien Tay and Helena Teede
    Citation: BMC Medicine 2025 23:151
    Content type: Guideline Published on:

  40. Communicating (dynamic) social norms is considered a promising tool to stimulate healthy and sustainable food choices. The aim of the present study was to evaluate to what extent a (dynamic) social norm interv...

    Authors: Sofia M. M. Wolfswinkel, Sanne Raghoebar, Josine M. Stuber, Emely de Vet and Maartje P. Poelman
    Citation: BMC Medicine 2025 23:150
    Content type: Research Published on:

  41. This prospective study aimed to examine the individual and combined population attributable fractions (PAFs) of stroke and its subtypes associated with reproductive factors among Chinese postmenopausal women, ...

    Authors: Weidi Sun, Jing Wu, Shiyi Shan, Leying Hou, Zeyu Luo, Jiali Zhou and Peige Song
    Citation: BMC Medicine 2025 23:149
    Content type: Research Published on:

  42. The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.

    Authors: Chenting Zhang, Bihua Zhong, Qian Jiang, Wenju Lu, Hongkai Wu, Yue Xing, Xuefen Wu, Zizhou Zhang, Yulin Zheng, Peiwen Li, Zhenxiang Li, Ziying Lin, Yuqin Chen, Cheng Hong, Zhuxiang Zhao, Tingting Zhang…
    Citation: BMC Medicine 2025 23:148
    Content type: Research Published on:

  43. Priority setting for research on epidemic/pandemic-prone pathogens is essential for the allocation of limited resources to optimise impact. It involves the identification of gaps in knowledge crucial to effect...

    Authors: Emilia Antonio, Nicolas Pulik, Susan Khader Ibrahim, Adebisi Adenipekun, Shanthi Levanita, Isabel Foster, Dorothy Chepkirui, Eli Harriss, Louise Sigfrid and Alice Norton
    Citation: BMC Medicine 2025 23:147
    Content type: Research Published on:

  44. Individuals who smoke tend to have a lower body mass index (BMI) but face an increased risk of obesity-related diseases. This study investigates this paradox from the perspective of gut microbiota.

    Authors: Yiting Duan, Chengquan Xu, Wenjie Wang, Xiaoyan Wang, Nuo Xu, Jieming Zhong, Weiwei Gong, Weifang Zheng, Yi-Hsuan Wu, April Myers, Lisa Chu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Min Yu, Wei He…
    Citation: BMC Medicine 2025 23:146
    Content type: Research Published on:

  45. Authors: Pengfei Huang, Yanqi Liu, Yue Li, Yu Xin, Chuanchuan Nan, Yinghao Luo, Yating Feng, Nana Jin, Yahui Peng, Dawei Wang, Yang Zhou, Feiyu Luan, Xinran Wang, Xibo Wang, Hongxu Li, Yuxin Zhou…
    Citation: BMC Medicine 2025 23:143
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2025 23:79

  46. Authors: Jessica L. Griffiths, Katherine R. K. Saunders, Una Foye, Anna Greenburgh, Ciara Regan, Ruth E. Cooper, Rose Powell, Ellen Thomas, Geoff Brennan, Antonio Rojas-García, Brynmor Lloyd-Evans, Sonia Johnson and Alan Simpson
    Citation: BMC Medicine 2025 23:141
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2024 22:564

  47. Denosumab, a drug that inhibits RANKL to reduce bone resorption in osteoporotic postmenopausal women, has been shown to improve semen quality in a subgroup of infertile men. This study aimed to investigate the...

    Authors: Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Ida Marie Boisen, Lív Bech Árting, Anne Jørgensen, Anders Juul and Martin Blomberg Jensen
    Citation: BMC Medicine 2025 23:145
    Content type: Research Published on:

  48. The long-term psychiatric and neuropsychiatric sequelae of COVID-19 across diverse populations remain not fully understood. This cohort study aims to investigate the short-, medium-, and long-term risks of psy...

    Authors: Yi Chai, Ivan C. H. Lam, Kenneth K. C. Man, Joseph F. Hayes, Eric Y. F. Wan, Xue Li, Celine S. L. Chui, Wallis C. Y. Lau, Xiaoyu Lin, Can Yin, Min Fan, Esther W. Chan, Ian C. K. Wong and Hao Luo
    Citation: BMC Medicine 2025 23:144
    Content type: Research Published on:

  49. Clinical prediction models (CPMs) estimate an individual’s risk of current or future outcome events, using information available about the individual at the time of prediction. While most CPMs are developed to...

    Authors: Glen P. Martin, Alexander Pate, Siân Bladon, Matthew Sperrin and Richard D. Riley
    Citation: BMC Medicine 2025 23:142
    Content type: Debate Published on:

  50. Lennox-Gastaut syndrome (LGS) is a severe encephalopathic disease that leads to a decrease in the quality of life, physical injury, psychosocial impairment, and a significant increase in treatment costs. Canna...

    Authors: Zahra Goudarzi, Farhad Lotfi, Rahil sadat Shahtaheri, Nasrin Moradi, Mohsen Taghizadeh and Khosro Keshavarz
    Citation: BMC Medicine 2025 23:135
    Content type: Research Published on:
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